Research & Publications

Selection of Publications

High levels of anti-HIV-1 envelope antibodies in cerebrospinal fluid as compared to serum from patients with AIDS dementia complex

Trujillo JR, Navia BA, Worth J, Lucey DR, McLane MF, Lee TH, Essex M.
J Acquir Immune Defic Syndr Hum Retrovirol. 1996 May 1;12(1):19-25. doi: 10.1097/00042560-199605010-00003

Identification of the envelope V3 loop as a determinant of a CD4-negative neuronal cell tropism for HIV-1

Trujillo JR, Wang WK, Lee TH, Essex M.
Virology. 1996 Mar 15;217(2):613-7. doi: 10.1006/viro.1996.0158.

Neuropathogenesis of HIV-1 Infection Microglia infection by HIV has been pathologically associated with “HIV encephalitis”. Neurons and astrocytes infection by HIV has been associated with “HIV encephalopathy”. The HIV T tropic phenotype is responsible for astrocyte/neuron infection in absence of CD4 receptor and some cases the presence of CXCR4.

Neurologic manifestations of AIDS: a comparative study of two populations from Mexico and the United States

Trujillo JR, Garcìa-Ramos G, Novak IS, Rivera VM, Huerta E, Essex M.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):23-9.

Neuropathogenesis of HIV-1 infection

Trujillo JR
Thesis (Doctor of Science)–Harvard School of Public Health, 1995

Evaluation of autoantibodies to brain proteins in patients with AIDS dementia complex

Trujillo JR, Navia B, McLane MF, Worth J, Lee TH, Essex M.
M. J AIDS, 1994, 7:103-108

Molecular mimicry between the human immunodeficiency virus type 1 gp120 V3 loop and human brain proteins

Trujillo JR, McLane MF, Lee TH, Essex M.
J Virol. 1993 Dec;67(12):7711-5. doi: 10.1128/JVI.67.12.7711-7715.1993.

Molecular mimicry Immunologically cross-reactive proteins in the human brain that resemble the V3 loop of HIV GP120 have been identified. An immune response to the V3 loop that generates cross-reactive antibodies to cellular proteins may be an autoimmune mechanism by which HIV can damage the central nervous system

Stereotactic Biopsy in Cerebral Lesions of AIDS

Gildenberg PL, Langford L, Kim JH, Trujillo JR.
Acta Neurochir Suppl (Wien). 1993;58:68-70. doi: 10.1007/978-3-7091-9297-9_15.

Assessment of nutritional status, nutrient intake, and nutrition support in AIDS patients

Trujillo EB, Borlase BC, Bell SJ, Guenther KJ, Swails W, Queen PM, Trujillo JR.
J Am Diet Assoc. 1992 Apr;92(4):477-8.

Ganciclovir in the treatment of CMV infection in AIDS patients with neurologic complication

I.S. Novak, Trujillo JR, Rivera VM.
Neurology 1989 Jan 39:379-380

Physician and Scientist, in neuroscience and molecular virology